Seboregulating

Seboregulation activity test and count of closed and open comedones

Regulatory reference: Guidelines to Commission Regulation (EU) No 655/2013
Claim: Non-comedogenic and Seboregulating
Application field: Visage and body cosmetics for oily skin.
Description of the test: Sebometric measurements in triplicate performed with Sebometer® at T=0 and T=X days after the treatment. Measurements will be performed on the cheeks after treatment. The untreated forehead will be used as a control. The measurements will compensate for circadian rhythms and will therefore be performed at the same time during the day. Open and closed comedones will be counted under Wood’s lamp illumination. Clinical evaluation of high resolution imaging will be performed using a contrast system at T=0 and after X days of treatment.
Posted in Acne, Seboregulating, Non-comedogenic, Claim for cosmetics

5α-reductase inhibition efficacy test by mRNA analysis on dermal papillae cells

Regulatory reference: Proprietary method
Claim: Seboregulating
Application field: Active ingredients or finished products.
Description of the test: Quantification of the changes in the gene expression of 5α-reductase in human dermal papilla cells. Demonstration of the efficacy of the ingredient or finished product in reducing the expression of mRNA codifying for 5α-reductase type I or II.
Posted in Acne, Seboregulating, Claim for cosmetics

5α-reductase inhibition efficacy test by mRNA analysis

Regulatory reference: Proprietary method
Claim: Seboregulating and Hair loss protection
Application field: Active ingredients or finished products.
Description of the test: Quantification of the changes in the gene expression of 5α-reductase in murine Balb/3T3 fibroblasts. Demonstration of the efficacy of the ingredient or finished product in reducing the expression of mRNA codifying for 5α-reductase type I or II.
Posted in Acne, Seboregulating, Hair loss protection, Hair products, Claim for cosmetics

5α-reductase inhibition efficacy test

Regulatory reference: Proprietary method
Claim: Seboregulating and Hair loss protection
Application field: Active ingredients or finished products.
Description of the test: Analysis of the in vitro expression of the 5α-reductase enzyme by real time PCR in comparison with untreated substrates for the evaluation of inhibition effects. Demonstration of the efficacy of the ingredient or finished product in reducing the expression of mRNA codifying for 5α-reductase type I or II.
Posted in Acne, Seboregulating, Hair loss protection, Hair products, Claim for cosmetics

Lipase stimulation efficacy test

Regulatory reference: Proprietary method
Claim: Anti-cellulite and Seboregulating
Application field: Active ingredients or finished products.
Description of the test: Analysis of the activation of the activity of enzymatic lipase in a controlled triglyceride hydrolysis reaction.
Posted in Acne, Anti-cellulite, Seboregulating, Cellulite, Claim for cosmetics