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Claim for cosmetics

Usage test – Required D-Value (RDV)

Regulatory reference: Proprietary method
Claim: Efficacy of preservatives
Application field: Cosmetic products.
Description of the test: In vitro and in vivo evaluation RDV for the determination of the PAO (Period After Opening).
Posted in Make up, Preservative systems, Claim for cosmetics, Efficacy of preservatives

Evaluation of the microbial contamination risk and water activity

Regulatory reference: ISO 29621
Claim: Free water percentage calculation and Low microbial contamination risk
Application field: Cosmetics.
Description of the test: Evaluation of the risk of microbial contamination in a cosmetic product by ISO 29621 method for the determination of water activity (Aw) parameter.
Posted in Make up, Preservative systems, Claim for cosmetics, Free water percentage calculation, Low microbial contamination risk

Antimicrobial activity test vs Propionibacterium acnes

Regulatory reference: Proprietary method
Claim: Anti-acne
Application field: Cosmetics and raw cosmetic ingredients.
Description of the test: Evaluation of the anti-acne efficacy by testing the inhibition of the proliferation of Propionibacterium acnes by an ingredient or finished product.
Posted in Acne, Anti-acne, Cosmetic raw materials

Antioxidant efficacy test: ORAC Test

Regulatory reference: UE Regulations
Claim: Antioxidant
Application field: Active ingredients for cosmetics products and medical devices.
Description of the test: Quantification of the antioxidant efficacy through ORAC (Oxygen Radical Absorbance Capacity) test.
Posted in Anti age, Antioxidant, Claim for cosmetics

Quantification of trace substances and impurities

Regulatory reference: UE Regulation
Claim: Titer of substances
Application field: Cosmetics and medical devices.
Description of the test: Analysis of trace substances, residues and impurities for quality control purposes through UPLC or GC-MS. Includes sample preparation.
Posted in Filter devices, shielding films and plasters, Cosmetic raw materials, Raw materials for medical devices, Surgical devices and medications, Claim for cosmetics, Claim for medical devices, Titer of substances

Quantification of the titer of substances

Regulatory reference: Regulation 1223/209
Claim: Titer of substances and Limit of preservatives
Application field: Preservatives, dyes, sunscreen filters.
Description of the test: Quantification method for the measurement of the titer of substances by HPLC, UPLC, GC-MS after preparative steps.
Posted in Heating and cooling products, Mucoadhesive products, Cosmetic raw materials, Detergents, Raw materials for medical devices, Substance-based, Surgical devices and medications, Claim for cosmetics, Claim for medical devices, Titer of substances, Limit of preservatives

Stability test

Regulatory reference: ICH or ISO
Claim: Accelerated stability tests
Application field: Medical devices and cosmetics.
Description of the test: Accelerated stability test according to ICH guidelines and ISO regulatory requirements, for medical devices and cosmetics.
Posted in Filter devices, shielding films and plasters, Heating and cooling products, Mucoadhesive products, Protection and barrier effect, Accelerated stability test, Substance-based, Surgical devices and medications, Make up, Claim for cosmetics, Claim for medical devices, Accelerated stability tests

Hair loss prevention efficacy test

Regulatory reference: Guidelines to Commission Regulation (EU) No 655/2013
Claim: Hair loss protection
Application field: Cosmetic products for hair and scalp treatment.
Description of the test: Clinical objective evaluation with high resolution imaging.
Pull test: count of the number of hairs collected under standardized traction. Trichographic analysis through cell biology techniques, and evaluation of the biological activity of collected hairs from each volunteer through MTT evaluation of cell vitality.
 
    Trichoscan phototrichogram:
  • Hair density in the target region (number of hairs/cm2);
  • Growth rate (mm/day);
  • Percentage of hairs in anagen phase;
  • Number of hairs in anagen phase.
Posted in Hair loss protection, Hair products, Claim for cosmetics

Lenitive and anti-itching efficacy test during acute phases of induced irritation

Regulatory reference: Guidelines to Commission Regulation (EU) No 655/2013
Claim: Lenitive effect and Itch soothing
Application field: Visage and body cosmetics.
Description of the test: Instrumental measurements with Minolta CR200 colorimeter performed to determine the phototype of the predefined skin region and the correlated MEDu. The hemoglobin content of the target area is measured using a Courage MX18 Mexameter®-Khazaka GmbH. Lenitive, soothing and anti-itching efficacy is measured against histamine, UV or chemically induced irritation.
Posted in Itch soothing, Lenitive effect, Lenitive products, Claim for cosmetics

Evaluation of depigmenting efficacy

Regulatory reference: Guidelines to Commission Regulation (EU) No 655/2013
Claim: Reduces skin blemishes, Skin whitening and Depigmenting action
Application field: Visage and body cosmetic products.
Description of the test: Instrumental measurements performed using a Minolta CR200 colorimeter will be performed at T=0 and T=X days (to be defined by previous agreement with the sponsor) in order to evaluate changes in the pigmentation of the treated area. The measurements will be performed at each time point in the same area. Acquisition of high definition images will be performed at T=0 and T=X days using a macro objective with color normalization and coaxial circular flash.
Posted in Skin whitening, Blemish reduction, depigmenting, tanning, Reduces skin blemishes, Claim for cosmetics